[HTML][HTML] Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: an evaluation of in vitro, in vivo methodologies and human studies
JWC Alffenaar, JEM de Steenwinkel… - Frontiers in …, 2022 - frontiersin.org
… of assessing and reporting PKPD of anti-tuberculosis drugs when … the extent of the drug
by performing time-kill kinetic studies, … pre-clinical models are useful in the tuberculosis drug …
by performing time-kill kinetic studies, … pre-clinical models are useful in the tuberculosis drug …
[HTML][HTML] Pre-clinical tools for predicting drug efficacy in treatment of tuberculosis
H Margaryan, DD Evangelopoulos, L Muraro Wildner… - Microorganisms, 2022 - mdpi.com
… In vitro time kill-kinetics assays can be adopted in a predictive preclinical modelling
framework to assess anti-tuberculosis drug activity. This provides important information on the …
framework to assess anti-tuberculosis drug activity. This provides important information on the …
Advanced Quantification Methods To Improve the 18b Dormancy Model for Assessing the Activity of Tuberculosis Drugs In Vitro
ED Pieterman, MJ Sarink, C Sala, ST Cole… - Antimicrobial agents …, 2020 - Am Soc Microbiol
… Therefore, as described in this paper, time-kill kinetics assays … The role of the time-kill
kinetics assay as part of a preclinical … of anti-tuberculosis drugs. Tuberculosis (Edinb) 105:80–85. …
kinetics assay as part of a preclinical … of anti-tuberculosis drugs. Tuberculosis (Edinb) 105:80–85. …
Higher Dosing of Rifamycins Does Not Increase Activity against Mycobacterium tuberculosis in the Hollow-Fiber Infection Model
ED Pieterman, S van den Berg… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
… The role of the time-kill kinetics assay as part of a preclinical modeling framework for
assessing the activity of anti-tuberculosis drugs. Tuberculosis (Edinb) 105:80–85. …
assessing the activity of anti-tuberculosis drugs. Tuberculosis (Edinb) 105:80–85. …
[HTML][HTML] Preclinical models of nontuberculous mycobacteria infection for early drug discovery and vaccine research
E Rampacci, V Stefanetti, F Passamonti… - Pathogens, 2020 - mdpi.com
… methods to evaluate the activity of drugs are introduced. … Finally, by performing time-kill
assays, researchers can obtain … To sum up, in this section, we reviewed the strategies of DST …
assays, researchers can obtain … To sum up, in this section, we reviewed the strategies of DST …
[HTML][HTML] Handling the hurdles on the way to anti-tuberculosis drug development
PF Dalberto, EV De Souza, BL Abbadi… - Frontiers in …, 2020 - frontiersin.org
… in whole-cell assays to evaluate their activity against the … tuberculosis, or in time-kill curves
to have their mechanism of … in toxicology studies during preclinical development. However, it …
to have their mechanism of … in toxicology studies during preclinical development. However, it …
Development of new tuberculosis drugs: translation to regimen composition for drug-sensitive and multidrug-resistant tuberculosis
… time-kill assays obtained from high-throughput screening in early discovery are used to
calculate PK-PD target calculations in late preclinical … in vitro assessment of drug activity, since …
calculate PK-PD target calculations in late preclinical … in vitro assessment of drug activity, since …
Pharmacodynamics and Bactericidal Activity of Combination Regimens in Pulmonary Tuberculosis: Application to Bedaquiline-Pretomanid-Pyrazinamide
MA Lyons - Antimicrobial Agents and Chemotherapy, 2022 - Am Soc Microbiol
… phase 2A studies to assess early bactericidal activity (EBA), … a PKPD model of Mycobacterium
tuberculosis killing kinetics … drug contributions to BPaZ were also illustrated with time-kill …
tuberculosis killing kinetics … drug contributions to BPaZ were also illustrated with time-kill …
[图书][B] Translating Nonclinical Findings to Prioritize Sterilizing Multi-Drug Regimens for the Treatment of Tuberculosis
J Ernest - 2022 - search.proquest.com
… time-kill assays obtained from high-throughput screening in early discovery are used to
calculate PK-PD target calculations in late preclinical … in vitro assessment of drug activity, since …
calculate PK-PD target calculations in late preclinical … in vitro assessment of drug activity, since …
[HTML][HTML] Unraveling antibiotic resistance mechanisms in Mycobacterium abscessus: the potential role of efflux pumps
SE Mudde, JA Schildkraut, NC Ammerman… - Journal of Global …, 2022 - Elsevier
… and verapamil to evaluate their potentiating capacity. … drugs in preclinical models [19,20].
Its capacity to inhibit … at which the time-kill kinetics assays were performed (Section 2.6.). On …
Its capacity to inhibit … at which the time-kill kinetics assays were performed (Section 2.6.). On …